個人簡歷

教育簡歷

• 2011年8月 - 2015年5月， 杜克大學(Duke University)👮🏻🧚🏻，環境化學與毒理學，博士

• 2009年2月 - 2011年2月， 浦項工業大學（POSTECH）🪷，環境分析化學，碩士

• 2002年9月 - 2006年7月👱🏼， 西安交通大學🐘，環境工程系，學士

工作簡歷

• 2022年3月 - 至今，沐鸣2平台🧑🏻‍🎄👩🏿‍⚕️，沐鸣2开户，教授

• 2016年12月 - 2022年3月👰🏻‍♀️，新加坡南洋理工大學(Nanyang Technological University)，土木環境工程系，助理教授（終身軌）

• 2015年5月 - 2016年12月，美國The Scripps Research Institute (TSRI, La Jolla)，代謝組學中心👭🏼，博士後

• 2006年7月 - 2009年2月，中國海洋石油天津分公司，EHS工程師

碩士🚴🏻‍♀️、博士生導師/方向

       課題組主要課題方向為化學品暴露以及環境健康，目前主要項目集中在“暴露組學”方法開發，同時利用高分辨質譜代謝組學等系統生物學方法研究汙染物毒性機理和蛋白靶點🙇‍♀️。目前課題組主要圍繞暴露組學和其健康效應等課題方向🕶，有以下幾個核心方向以及組內近幾年部分相關論文。

       方向一🎁：建立暴露組學數據庫和質譜分析方法學平臺(Zhao et al, EHP, 2021; Jia et al., ES&T, 2019；Yang et al. ACA, 2019)。

       方向二：研究暴露組概念下，汙染物混合物在環境劑量條件下的毒性和健康風險(Liu et al., EHP, 2020; Dong et al. ES&T, 2019; Peng et al. ES&T, 2020; Zhang et al., ES&T, 2020; Fang et al., ES&T, 2015; Fang et al., EHP, 2015; Fang et al., ETC, 2014)。

       方向三：研究暴露組跟細菌組（腸道菌等）之間的相互作用以及對於宿主健康影響（Wang et al., PNAS, 2021; Zhang et al., ES&T 2018；Keerthisinghe et al. EI, 2020）。

       方向四：通過系統生物學方法（代謝組學+化學蛋白組學等）和計算毒理學等手段研究汙染物或者藥物毒性機理(Beyer* and Fang* et al. Nature Chemical Biology, 2018; Xu et al., ES&T 2020; Xu et al., Anal. Chem. 2021; Xu et al. ES&T 2021)🪁。

學術兼職

• Environmental Pollution (Elsevier) 副主編😬🤦‍♂️，2021-至今

• Environmental Science: Processes & Impacts (RSC) 編委🦸🏼‍♂️，2020-至今

• ACS ES&T Water編委🐕‍🦺，2021-至今

• Environment International (Elsevier) 編委🧗🏻‍♀️，2018-至今

• Environmental Research (Elsevier) 編委，2019-至今

• Chemosphere (Elsevier) 編委🙌，2021-至今

• EXPOSOME (Oxford) 編委，2020-至今

• Environmental International (Elsevier)客座編輯🙌，2021

• Journal of Hazardous Material (Elsevier)客座編輯，2020

• 中國生物物理代謝組學協會委員👀，2019-至今

• SSMS（新加坡質譜協會）委員🤳，2018-至今

• 國際代謝組學協會Metabolomics Society Committee member，2022

• 新加坡環保部特邀室內空氣專家組成員, 2017-至今

• 新加坡環保部特邀土地質量標準專家組成員🌜，2019-至今

榮譽與獎勵

• 2020年，海外高層次人才引進計劃（青年項目）

• 2017年🦚，Environmental Chemistry and Toxicology 年度10佳論文

• 2011年，Outstanding publication award, Brain of Korea (BK21)

科學研究

主持和參與的主要項目/課題

• Investigating opportunities to reduce microfibre pollution from the fashion industry through textile design and manufacturing innovation主持🩹，UNDP-The Future Forum （聯合國發展署）

• Pesticide formulation survey in Singapore主持, NEA（新加坡環保署）

• Indoor Air Pollutant Control Strategy: With Special Focus on Haze Episode主持, BCA（新加坡住建局）

• Autologous PKD iPSC-derived kidney organoids: a novel platform for personalized drug screening分項目主持, NMRC（新加坡國家醫學研究所）

• Bedside to bench and back again: evaluating Neisseria spp. as novel respiratory pathobionts using systems biology分項目主持, NMRC（新加坡國家醫學研究所）

• Potential Impacts on Indoor Environmental Quality, Human Health, Thermal Comfort, and ACMV Operations主持, JTC （裕廊集團）

• Assessing The Public Health Risks And Enhancing The Health of Singapore's Built Environment主持, NEA （新加坡環保署）

• Biodiversity and Bioprospecting of Magnetotactic Bacteria - An Overlooked Biotechnological Resource in the Tropical Marine Environment of Singapore參與, NRF

• Metabolite directed detoxification主持,MOE Tier 1 （新加坡教育部）

• Novel methods for assessing nano-microbiome interactions of ingested engineered nanomaterials: Towards safer-by-design, biocompatible nano-materials in food applications from the gut microbial perspective主持, NTU-Harvard （南洋理工-哈佛大學合作項目）

• The Interaction between Emerging Organic Contaminants and Gut Microbiome: Implication on 'Gut Green Chemistry' and Healthcare主持, MOE AcRF Tier 1, NTU-SUG （新加坡教育部）

• Long-Term Environmental Behaviour Evaluation for Municipal Solid Waste Thermal Treatment Residues Used in Road Construction參與, NEA （新加坡環保署）

教研成果

獲獎：

2020年，School Teaching Excellence Award，Nanyang Technological University

代表性論文：

1. Mengjing Wang, Qianqian Li, Meifang Hou, Louisa LY Chan, Meng Liu, Soo Kai Terd, Ting Dong, Yun Xia*, Sanjay H Chotirmalld, Mingliang Fang*. Inactivation of common airborne antigens by perfluoroalkyl chemicals modulates early-life allergic asthma. Proceedings of the National Academy of Sciences of the United States of America. 2021

2. Beyer, B. A.#, Fang, M.# （Equal Contribution）, Sadrian, B., Montenegro-Burke, J. R., Plaisted, W. C., Kok, B. P., ... & Lairson, L. L*. (2018). Metabolomics-based discovery of a metabolite that enhances oligodendrocyte maturation. Nature Chemical Biology,  14(1), 22-28. https://doi.org/10.1038/nchembio.2517

3. M Fang, L Hu, D Chen, Y Guo, J Liu, C Lan, J Gong, B Wang. “Exposome” in Human Health: Utopia or Wonderland? The Innovation, 100172, 2021

4. Fanrong Zhao, Li Li, Yue Chen, Yichao Huang, Tharushi Prabha Keerthisinghe, Agnes Chow, Ting Dong, Shenglan Jia, Shipei Xing, Benedikt Warth, Tao Huan and Mingliang Fang*. Risk-based Chemical Ranking and Generating a Prioritized Human Exposome Database. Environmental Health Perspective. 2021.

5. Liu, M., Jia, S., Dong, T., Zhao, F., Xu, T., Yang, Q., ... & Fang, M*. (2020). Metabolomic and Transcriptomic Analysis of MCF-7 Cells Exposed to 23 Chemicals at Human-Relevant Levels: Estimation of Individual Chemical Contribution to Effects. Environmental Health Perspectives  https://doi.org/10.1289/EHP6641

6. Fang, M., Webster, T. F., Ferguson, P. L., & Stapleton, H. M*. (2015). Characterizing the peroxisome proliferator-activated receptor (PPARγ) ligand binding potential of several major flame retardants, their metabolites, and chemical mixtures in house dust. Environmental Health Perspectives,  123(2), 166-172. https://doi.org/10.1289/ehp.1408522

7. Pillai, H. K., Fang, M., Beglov, D., Kozakov, D., Vajda, S., Stapleton, H. M., ... & Schlezinger, J. J*. (2014). Ligand Binding and Activation of PPAR γ by Firemaster® 550: Effects on Adipogenesis and Osteogenesis in Vitro. Environmental Health Perspectives,  122(11), 1225-1232. https://doi.org/10.1289/ehp.1408111 

8. Hoffman, K.#, Fang, M.# （Equal Contribution）, Horman, B., Patisaul, H. B., Garantziotis, S., Birnbaum, L. S., & Stapleton, H. M. *(2014). Urinary tetrabromobenzoic acid (TBBA) as a biomarker of exposure to the flame retardant mixture Firemaster® 550. Environmental Health Perspectives,  122(9), 963-969. https://doi.org/10.1289/ehp.1308028

9. Liu, Min; Jiang, Jie; Jie, Zheng; Huan, Tao; Gao, Bei ; Fei, Xunchang; Wang, Yulan; Fang, Mingliang*. RTP: One Effective Platform to Probe Reactive Compound Transformation Products and Its Applications for a Reactive Plasticizer BADGE. Environmental Science & Technology. 2021. 

10. Xu, Tengfei; Chen, Liyan; Lim, Yan Ting; Zhao, Haoduo; Chen, Hongjin; Chen, Mingwei; Huan, Tao; Huang, Yichao; Sobota, Radoslaw ; Fang, Mingliang*. (2021). Systems Biology-Guided Chemical Proteomics to Discover Protein Targets of Monoethylhexyl Phthalate in Regulating Cell Cycle. Environmental Science & Technology. 2021, 55, 3, 1842–1851.  

11. Xu, T., Lim, Y. T., Chen, L., Zhao, H., Low, J. H., Xia, Y., ... & Fang, M*. (2020). A Novel Mechanism of Monoethylhexyl Phthalate in Lipid Accumulation via Inhibiting Fatty Acid Beta-Oxidation on Hepatic Cells. Environmental Science & Technology. https://doi.org/10.1021/acs.est.0c01073

12. Zhang, Y., Liu, M., Peng, B., Jia, S., Koh, D., Wang, Y., ... & Fang, M*. (2020). Impact of Mixture Effects between Emerging Organic Contaminants on Cytotoxicity: A Systems Biological Understanding of Synergism between Tris (1, 3-dichloro-2-propyl) phosphate and Triphenyl Phosphate. Environmental Science & Technology,  54(17), 10722-10734. https://doi.org/10.1021/acs.est.0c02188

13. Huang, Y., & Fang, M*. (2020). Nutritional and Environmental Contaminant Exposure: A Tale of Two Co-Existing Factors for Disease Risks. Environmental Science & Technology. https://doi.org/10.1021/acs.est.0c05658

14. M Liu, B Peng, G Su, M Fang*. Reactive Flame Retardants: Are They Safer Replacements? Environmental Science & Technology. 2021. 

15. Setyawati, M. I., Singh, D., Krishnan, S. P., Huang, X., Wang, M., Jia, S., Fang, M., ... & Poh, T. Y. (2020). Occupational Inhalation Exposures to Nanoparticles at Six Singapore Printing Centers. Environmental Science & Technology, 54(4), 2389-2400. https://doi.org/10.1021/acs.est.9b06984 

16. Peng, B., Liu, M., Han, Y., Wanjaya, E. R., & Fang, M*. (2019). Competitive biotransformation among phenolic xenobiotic mixtures: Underestimated risks for toxicity assessment. Environmental Science & Technology, 53(20), 12081-12090. https://doi.org/10.1021/acs.est.9b04968

17. Dong, T.#, Zhang, Y.#, Jia, S., Shang, H., Fang, W., Chen, D., & Fang, M*. (2019). Human indoor exposome of chemicals in dust and risk prioritization using EPA’s ToxCast database. Environmental Science & Technology,  53(12), 7045-7054. https://doi.org/10.1021/acs.est.9b00280

18. Jia, S., Xu, T., Huan, T., Chong, M., Liu, M., Fang, W., & Fang, M*. (2019). Chemical isotope labeling exposome (CIL-EXPOSOME): one high-throughput platform for human urinary global exposome characterization. Environmental Science & Technology,  53(9), 5445-5453. https://doi.org/10.1021/acs.est.9b00285

19. Zhang, Y., Keerthisinghe, T. P., Han, Y., Liu, M., Wanjaya, E. R., & Fang, M*. (2018). “Cocktail” of xenobiotics at human relevant levels reshapes the gut bacterial metabolome in a species-specific manner. Environmental Science & Technology,  52(19), 11402-11410. https://doi.org/10.1021/acs.est.8b02629

20. Fang, M., Webster, T. F., & Stapleton, H. M*. (2015). Effect-Directed Analysis of Human Peroxisome Proliferator-Activated Nuclear Receptors (PPARγ1) Ligands in Indoor Dust. Environmental Science & Technology, 49(16), 10065-10073. https://doi.org/10.1021/acs.est.5b01524

21. Fang, M., Webster, T. F., & Stapleton, H. M*. (2015). Activation of Human Peroxisome Proliferator-Activated Nuclear Receptors (PPARγ1) by Semi-Volatile Compounds (SVOCs) and Chemical Mixtures in Indoor Dust. Environmental Science & Technology,  49(16), 10057-10064. https://doi.org/10.1021/acs.est.5b01523 

22. Fang, M., & Stapleton, H. M.* (2014). Evaluating the bioaccessibility of flame retardants in house dust using an in vitro Tenax bead-assisted sorptive physiologically based method. Environmental Science & Technology,  48(22), 13323-13330. https://doi.org/10.1021/es503918m

23. Fang, M., Webster, T. F., Gooden, D., Cooper, E. M., McClean, M. D., Carignan, C., ... & Stapleton, H. M*. (2013). Investigating a novel flame retardant known as V6: measurements in baby products, house dust, and car dust. Environmental Science & Technology,  47(9), 4449-4454. https://doi.org/10.1021/es400032v

24. Chen, Xing; Zhang, Keda; Yin, Zhihong; Fang, Mingliang; Pu, Weidan; Liu, Zhening; Li, Lei; Sinues, Pablo; Dallmann, Robert; Zhou, Zhen; Li, Xue. Online Real-Time Monitoring of Exhaled Breath Particles Reveals Unnoticed Transport of Non-Volatile Drugs from Blood to Breath. Analytical Chemistry, 2021. 

25. T Xu, H Zhao, M Wang, A Chow, M Fang*. Metabolomics and in-silico docking-directed discovery of small-molecule enzyme targets. Analytical Chemistry. 2021.

26. Xing, S., Hu, Y., Yin, Z., Liu, M., Tang, X., Fang, M., & Huan, T.* (2020). Retrieving and Utilizing Hypothetical Neutral Losses from Tandem Mass Spectra for Spectral Similarity Analysis and Unknown Metabolite Annotation. Analytical Chemistry (Washington),  92(21), 14476-14483. https://doi.org/10.1021/acs.analchem.0c02521 

27. Fang, M., Ivanisevic, J., Benton, H. P., Johnson, C. H., Patti, G. J., Hoang, L. T., ... & Siuzdak, G*. (2015). Thermal degradation of small molecules: a global metabolomic investigation. Analytical Chemistry (Washington),  87(21), 10935-10941. https://doi.org/10.1021/acs.analchem.5b03003

28. Warth, B., Spangler, S., Fang, M., Johnson, C. H., Forsberg, E. M., Granados, A., ... & Montenegro-Burke, J. R. (2017). Exposome-Scale Investigations Guided by Global Metabolomics, Pathway Analysis, and Cognitive Computing. Analytical Chemistry 89(21), 11505–11513. https://doi.org/10.1021/acs.analchem.7b02759

29. Preindl, K., Braun, D., Aichinger, G., Sieri, S., Fang, M., Marko, D., & Warth, B*. (2019). A Generic Liquid Chromatography−Tandem Mass Spectrometry Exposome Method for the Determination of Xenoestrogens in Biological Matrices. Analytical Chemistry (Washington), 91(17), 11334–11342. https://doi.org/10.1021/acs.analchem.9b02446

30. H Zhao, Liu, Min, Y Lv, M Fang*. Dose-response Metabolomics and Pathway Sensitivity to Map Molecular Cartography of Bisphenol A Exposure. Environment International. 2021. 

31. D Wang, H Zhao, XunchangFei, SA Synder, M Fang*, M Liu*. A comprehensive review on the analytical method, occurrence, transformation and toxicity of a reactive pollutant: BADGE. Environment International. 2021.

32. Keerthisinghe, T. P., Wang, M., Zhang, Y., Dong, W., & Fang, M*. (2019). Low-dose tetracycline exposure alters gut bacterial metabolism and host-immune response:“Personalized” effect?. Environment International,  131, 104989. https://doi.org/10.1016/j.envint.2019.104989 

33. Keerthisinghe, T. P.#, Wang, F.#, Wang, M., Yang, Q., Li, J., Yang, J., ... & Fang, M*. (2020). Long-term exposure to TET increases body weight of juvenile zebrafish as indicated in host metabolism and gut microbiome. Environment International,  139, 105705.  https://doi.org/10.1016/j.envint.2020.105705

34. Fang, M., Getzinger, G. J., Cooper, E. M., Clark, B. W., Garner, L. V., Di Giulio, R. T., ... & Stapleton, H. M.* (2014). Effect‐directed analysis of Elizabeth River porewater: Developmental toxicity in zebrafish (Danio rerio). Environmental Toxicology and Chemistry,  33(12), 2767-2774. https://doi.org/10.1002/etc.2738

35. Fang, M.*, Guo, J., Chen, D., Li, A., Hinton, D. E., & Dong, W*. (2016). Halogenated carbazoles induce cardiotoxicity in developing zebrafish (Danio rerio) embryos. Environmental Toxicology and Chemistry,  35(10), 2523-2529. https://doi.org/10.1002/etc.3416. 

36. Yang, J. J., Han, Y., Mah, C. H., Wanjaya, E., Peng, B., Xu, T. F., ... & Fang, M. L*. (2020). Streamlined MRM method transfer between instruments assisted with HRMS matching and retention-time prediction. Analytica Chimica Acta,  1100, 88-96. https://doi.org/10.1016/j.aca.2019.12.002

37. Shenglan Jia, Magdiel Inggrid Setyawati, Min Liu, Tengfei Xu, Joachim Loo, Meilin Yan, Jicheng Gong, Sanjay H Chotirmall, Philip Demokritou, Kee Woei Ng, Mingliang Fang*. Association of Nanoparticle Exposure with Serum Metabolic Disorders of Healthy Adults in Printing Centres. Journal of Hazardous Materials, 128710, 2022

38. B Peng, H Zhao, TP Keerthisinghe, Y Yu, D Chen, Y Huang*, M Fang*. Gut microbial metabolite p-cresol alters biotransformation of bisphenol A: Enzyme competition or gene induction? Journal of Hazardous Materials 426, 2022. 

39. Mengjing Wang, Shenglan Jia, Agnes Chow, Mingliang Fang*. Polycyclic aromatic hydrocarbons (PAHs) in indoor environment are still imposing carcinogenic risk Journal of Hazardous Materials. Journal of Hazardous Material. 2020. 

40. TP Keerthisinghe, Q Yang, A Chow, M Fang*. Feeding State Greatly Modulates the Effect of Xenobiotics on Gut Microbiome Metabolism: A Case Study of Tetracycline. Journal of Hazardous Materials. 2021. doi.org/10.1016/j.jhazmat.2021.125441. 

41. Li, J.#, Dong, T.#, Keerthisinghe, T. P., Chen, H., Li, M., Chu, W., ... & Fang, M*. (2020). Long-term oxytetracycline exposure potentially alters brain thyroid hormone and serotonin homeostasis in zebrafish. Journal of Hazardous Materials, 123061. https://doi.org/10.1016/j.jhazmat.2020.123061

42. Huan, T., Forsberg, E. M., Rinehart, D., Johnson, C. H., Ivanisevic, J., Benton, H. P., Fang, M., ... & Thorgersen, M. P. (2017). Systems biology guided by XCMS Online metabolomics. Nature Methods,  14(5), 461-462. https://doi.org/10.1038/nmeth.4260

43. Guang-Lei Ma, Hartono Candra, Li Mei Pang, Juan Xiong, Yichen Ding, Hoa Thi Tran, Zhen Jie Low, Hong Ye, Min Liu, Jie Zheng, Mingliang Fang, Bin Cao, Zhao-Xun Liang*. Biosynthesis of Tasikamides via Pathway Coupling and Diazonium-Mediated Hydrazone Formation. Journal of the American Chemical Society. 2022.

44. GL Ma, HT Tran, ZJ Low, H Candra, LM Pang, QW Cheang, M Fang and ZX Liang*. Pathway Retrofitting Yields Insights into the Biosynthesis of Anthraquinone-Fused Enediynes. Journal of the American Chemical Society. 2021. 

45. Xunchang Fei, Mingliang Fang. Climate change affects land-disposed waste. Nature Climate Change, 2021.

46. Low, J. H., Li, P., Chew, E. G. Y., Zhou, B., Suzuki, K., Zhang, T., Fang, M. et.al (2019). Generation of human PSC-derived kidney organoids with patterned nephron segments and a de novo vascular network. Cell Stem Cell,  25(3), 373-387. https://doi.org/10.1016/j.stem.2019.06.009